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Toxoplasmosis, one of the most common infection, is a worldwide acquired human disease, caused by the Toxoplasma gondii, an obligatory intracellular parasite and exists in the tissues of felines, most mammals and birds. To evaluate the incidence and prognosis of toxoplasmosis in our patients, and to learn whether the intervention of an early diagnosis and care can prevent the disease outcome. The cases with positive anti-Toxoplasma IgM and IgG in patients admitted at the First Obstetrical Ward, Obstetrics and Gynecology Hospital “Prof Dr. Burgaz”, Iasi, during a 9 years period (1999-2007) were retrospectively studied. The diagnosis was stablished by a detection of antibodies by using EIA method. The clinical and laboratory findings, interventions and outcome were retrospectively studied. The study included 5 patients (3 with congenital forms, 2 with the acquired form). Three cases (60%) were diagnosed at the first trimester of gestation. In 2 cases, the outcome was favorable, and in one case was considered a sequel from an acute infection. In the last one, the serology was negative, but the clinical status and neuroradiological findings were suspicious of the latent infection. In 3 cases, the first and only risk factor was the transplacental transmission of Toxoplasma during gestation (2 cases of congenital and 1 of acquired toxoplasmosis). In all of them, the diagnosis was made late; in two cases, was established at second trimester, and in the last one at third trimester. One case of congenital infection was treated with spiramycin and the other one with pyrimethamine-sulfonamide. A screening of pregnant women for toxoplasmosis, an early diagnosis and intervention are mandatory, and they could prevent the sequel of the disease.Changes in pulmonary vascular resistance in a model of chronically hypoxic sheep.
Two isolated sheep lungs per animal were perfused with a constant flow of autologous blood. In one lung, the mean pulmonary arterial pressure and in the other the plethysmographic lung volume were measured. To simulate chronic hypoxia, the sheep breathed a hypoxic gas mixture. In normoxic experiments, the pulmonary vascular resistance (PVR) and
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