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B Lymphocyte Activation in the Absence of T Cell Help {#S4}
=====================================================
T follicular helper (T~FH~) cells, a subset of CD4^+^ T cells that are developmentally programmed to support B cell responses, have been shown to be the primary source of CCR7^+^IL-21^+^ T~FH~ cells during an acute HIV infection ([@B56], [@B57], [@B66]). However, not all B cells are generated in the T~FH~ pathway ([@B56], [@B57]), and in the absence of a functioning T~FH~ cell response, there is a decrease in plasmablast differentiation into long-lived plasma cells, and a decrease in antigen-specific IgG and IgM plasma cell production ([@B56]). There also appears to be a shift away from isotype switching
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