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The plasma pharmacokinetics of chlorpromazine (CPZ) and levomepromazine (LVP) were studied in 15 schizophrenic patients using an HPLC method with fluorescence detection. For comparison, data from a recent study with the same method in normal volunteers were also analyzed. In contrast to their normal subjects, plasma concentration-time data for CPZ and LVP in the schizophrenic patients showed two distinct peaks, the first presumably reflecting the absorption of the medication and the second coinciding with the trough of the plasma concentration profile. To illustrate the anomalous nature of the plasma concentration-time data from the schizophrenic patients, these data were fit to conventional compartmental models for drug distribution. The disappearance of the first peak in the patients was modeled as a process with a half-life of 56.4 h. The concentration-time data for the second peak were fit best to a three-compartmental model, with a lag time of 56.4 h, a distribution half-life of 4.7 h, and a terminal half-life of 8.0 h. This distribution phase half-life for the second peak was shorter than that of the first peak (56.4 versus 108.2 h). The mean (+/- SD) bioavailability of CPZ and LVP was calculated as 54 +/- 14% and 49 +/- 10%, respectively, for the schizophrenic patients. These data suggest that the absorption of CPZ and LVP was not diminished in this patient population but that there was severe drug binding to plasma proteins.Blunt gut injuries in children: a 10-year experience.
The management and outcome of children who sustained a blunt trauma to the abdomen and suffered peritonitis over a 10-year period were analyzed and compared with previously published reports. One hundred fifty-four (154) patients were admitted over the
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Port Chester is a town in Westchester County, New York, United States. As of the 2010 census, the town had a total population of 48,016. It is one of the five towns that comprise the New York City Metropolitan Area. Port Chester is home to Westchester County Airport.
History
Originally, it was part of the town of Yonkers. Port Chester was named in honor of Chester, one of the founder ships at the nearby Troy River. The town was organized from part of the Town of Ossining on January 1, 1785.
Former New York Jets owner Leon Hess, who had a farm in the town, and televangelist Pat
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The electrochemical oxidation of boron doped titanium carbide powder was performed in order to obtain a very thin boron doped TiC layer on TiO(2) colloidal particles. XPS and FTIR spectroscopy demonstrated that the boron is incorporated inside the TiC crystal in the form of B(2)O(3) up to the 2% level. The catalytic properties were evaluated by using cyclic voltammetry and found to be intermediate between a bare TiO(2) and a B-TiO(2) sample.Hollywood Is Brimming with Failed Liberal Films
It isn’t just that Hollywood liberals (and many other people) want things to stay the same. It’s that they’ve confused being pro-democracy with being pro-regime change. For example, the problem with Sully (Tom Hanks) is not that he tries to be a good cop and take down the crooked mayor; it’s that he’s in the right place at the wrong time. When he tries to subvert and arrest the mayor, it’s because he’s been framed by the good cop, and the cop isn’t as noble as he says he is.
Similarly, the problem with Wonder Woman (Gal Gadot) isn’t that she defends the rule of law; it’s that she’s in the right place at the wrong time. When she intervenes to save the wrong guy, it’s because she’s being framed by the good cop, and the cop