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* **Photoshop CS5** is the latest version that includes many new effects, an improved canvas, a faster work environment, and many other improvements. The features of Photoshop are contained in several panes that float on top of the image you’re working on. These are known as Layers and the various tools that you use for image creation and manipulation. You can view each of these panes by clicking the View button in the top-right corner. You can also click any Photoshop icon to open that feature. The following topics describe all of the panes and how you work in Photoshop. The Layer Pane The most important feature of Photoshop is the Layers panel, which shows all of the images, layers, and selections. The most basic use of the Layers panel is to open a new image and then add a layer. Figure 3-1 shows what a simple Layers panel looks like, and the next few steps show the steps to create a new layer. FIGURE 3-1 To create a new layer, open an image, click and drag the new layer control icon to the desired location (you may want to center it horizontally or vertically to better fit the image), and type a name for the layer. When you click OK, Photoshop opens a Layers palette, which should look like Figure 3-2. Click any thumbnail to open that layer in the image window. You can open layers for other images on your hard drive by clicking the Windows button and choosing Open Recent (or by pressing Ctrl+Shift+B). FIGURE 3-2 Any images you open in Photoshop should be made to the default dimensions: 300 pixels wide by 200 pixels high. It makes working with the layers and tools easier. To change the default width and height, select the image and press Ctrl+T (⌘-T on the Mac). You can also choose Window→Scale or press Ctrl+S (⌘-S) to stretch or shrink the image. * In the top-left corner of the Layers panel, you see a thumbnail of the current active layer. Click the thumbnail (shown in the top margin in Figure 3-2) to switch to the background layer. Click a thumbnail to open an image that contains that layer. You can use this feature to work with layers and the panels in the Background layer of an image. * The thumbnail on the right side of the panel is



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Watch the full Photoshop video tutorial And more about Photoshop Elements here. Elements is often overlooked in favour of the professional version, Photoshop. However, in many ways Elements is a more powerful version of the program than the professional version. While Photoshop continues to offer more advanced and powerful features and more control over its internals, this has come at the cost of complexity. Elements is a more logical and easier-to-use alternative to Photoshop. The remainder of this article contains tips, tricks and recommendations for the best way to get started with Photoshop Elements. To improve image quality, many Photoshop users simply use the Edit > Image > Adjust > Brightness/Contrast command in Elements. However, to remove noise and sharpen an image, Elements offers a number of tools that allow you to edit the individual colours in an image. You can even use Exposure to remove any unwanted parts of the image, including unwanted highlights, shadows and even spots. The effect is similar to the Lightroom’s Negative tool, but you don’t need to download a separate application for it. In this tutorial, we will look at some of the ways you can use the tools available in Elements to create some of the most useful effects in the program. Try Not to Use the Straight-Up Brightness/Contrast tool too much When you first open a new image in Photoshop Elements, you will be greeted with the following dialog: You may notice that the selection of a grey ellipse is likely to highlight the whole image, including unwanted areas. The bright and easy-to-use interface will do a great job at quickly creating a basic contrast effect. However, its default action when you press a key is to bring the image to its default brightness level of 100. If the target brightness of the image was anything less than 100, then you will be returned to the default brightness setting of the image. The straight-up Brightness/Contrast tool is only one of a set of options and tools that you can use to create a wide range of contrast effects. You don’t really need to use this tool that often, since all of the actions are the same as the default action. It is possible to use the whole toolset to create simple contrast effects, but it can take a little practice and familiarity with the different tools in the menus to achieve the best results. Additionally, a681f4349e



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The article by Geraghty, Al-Sayyed, *et al*. \[[@B1]\] in the current issue of the journal *Drug Safety*is truly remarkable. Because of the risk of thrombosis, many biologic therapies have been removed from use, leading to the loss of more than 30,000 lives since 2000. Several recombinant human antithrombins (Factor VIIa, FVIIa) have been developed to reverse the effects of this condition, but with mixed results. What Geraghty, Al-Sayyed, *et al*. \[[@B1]\] describe is a novel approach to the treatment of these complications. The authors demonstrate that heparin sodium both protects the site of tissue damage in a hamster model of venous thrombosis and is itself protective. The efficacy of heparin therapy is thus because of both its intrinsic effect and its addition to other anticoagulants such as warfarin. Heparin therapy prevents excessive thrombin generation in the clots that give rise to the new thrombi \[[@B2]\]. Moreover, heparin therapy has been shown to enhance thrombus dissolution and microvascular patency in animals. Heparin, in addition to its anti-thrombin activity, also reduces inflammation and vascular hyperpermeability \[[@B3]\]. These mechanisms of action of heparin have been confirmed by the earlier work of Fonta, Petit, *et al*. \[[@B4]\] in a mouse model of thrombosis. Because heparin is only effective at the site of tissue injury, a region of localized elevated thrombin generation, they have considered the possibility that augmenting the anti-thrombin activity of heparin might lead to increased protection of the microvasculature. Bouadir, El-Antri, *et al*. \[[@B5]\] have recently determined the anti-thrombin activity of several heparin derivatives, including low molecular weight heparin (LMWH). They found that LMWH inhibits thrombin activity, prolongs both the extrinsic and intrinsic pathways of coagulation and protects against thrombin-induced fibrin formation, as well as against tissue factor activation. Their goal was to improve anticoagulant therapy by obtaining a procoagulant



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Quality assurance in the management of testicular cancer. Results of the Testicular Cancer Cooperative Group. During 1975 the Testicular Cancer Cooperative Group, an organization composed of more than 100 clinical centers, was organized to promote the application of state-of-the-art therapy to the treatment of testicular cancer. The group has also cooperated with the American Academy of Pediatrics, the National Institutes of Health, the U.S. Public Health Service, and the American Medical Association in the formulation and dissemination of guidelines for the care of patients with testicular cancer. The best available clinical and laboratory techniques have been applied to the care of patients with testicular cancer. Standardized chemotherapy, including cyclophosphamide, cis-platinum, etoposide, and bleomycin, has been used to treat adolescents. The results of these treatments have been analyzed. Data are presented that have been collected from 95 percent of the pediatric and adult patients in Cooperative Group therapeutic trials, and 14 percent of the cases in the United States Cancer Surveillance Program of the National Cancer Institute. These data, obtained in the therapeutic trials, are presented by age, histologic grade, stage of the disease, and specific therapy. In the surveillance program, the results of the Surveillance Program for a 5-year period are presented by histology, stage, and survival. Finally, the results of the Prospective Surveillance of Testicular Cancer Study are presented. The lessons learned from these data provide a basis for planning the management of testicular cancer in the future.This invention relates to an apparatus for inspecting the bottom surfaces of bottles. The apparatus is particularly useful for inspecting the bottom surfaces of bottles having glass, plastic or composite surfaces, such as are commonly employed in the manufacture and sale of carbonated beverages and the like. Bottles of the foregoing types are frequently shipped in open cartons to beverage bottling plants where they are filled by machines which employ a variety of hand labor to complete the filling operation. Since the bottle bottom surfaces are not inspected before filling, it is virtually impossible for the bottler to guarantee that the bottoms of all of the bottles in a carton will be free of defects or blemishes, such as tooth marks or other imperfections. A number of problems result from the foregoing situation. First of all, there is a possibility that a number of the bottom surfaces of the bottles will be so damaged that the bottles will not be saleable as carbonated beverages. Secondly, when the bottles in a carton are inspected by



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Windows 7 Windows 8 Mac OS X 10.7 Linux 2.6.x Minimum 1024×768 display resolution 1024×768 display resolution High-end Dual Core CPU Intel Core i5-2500K @ 3.3 GHz AMD Phenom II X4 @ 2.6 GHz MacBook Pro, i7 13″ @ 2.5 GHz Minimum 4 GB RAM 4 GB RAM 6 GB RAM recommended Strictly 32-bit version of Daggerfall Unity C



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