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Hepatitis C virus (HCV) infection is associated with the development of liver cirrhosis and hepatocellular carcinoma (HCC) leading to significant morbidity and mortality. The effects of HCV infection on the risk of additional cancers, mostly among those who have been cured of liver cirrhosis or HCC, remain unknown. To address the issue of whether HCV infection is associated with an increased risk of cancer, we used the data from the 2007 Chinese National Cancer Incidence and Mortality Surveillance (CNCIMS) program. For a total of 293,057 HCV-seropositive individuals and 3,840,958 seronegative controls, a multivariate logistic regression model was applied to estimate the adjusted odds ratios (aORs) of 10 specific cancers with 95% confidence intervals (CIs) after stratification by gender, age, and occupation. It was found that the HCV-infected group was more likely to develop liver cancer, HCC, and lung and cervical cancer, and less likely to develop stomach cancer, breast cancer, and prostate cancer. There was an elevated risk for HCC in both males and females, and the risk of liver cancer, HCC and lung cancer increased with age and the risk of prostate cancer decreased with age. Male employees with the occupation of production operators, drivers, and farmers with HCV infection exhibited a significantly increased risk for stomach cancer (aORs = 1.42-1.54) and a decreased risk for liver cancer, HCC and prostate cancer (aORs = 0.83-0.95). We conclude that HCV infection is associated with an increased risk of liver cancer, HCC and lung cancer, and a decreased risk of stomach cancer, breast cancer, and prostate cancer. Male employees in the occupations of production operators, drivers, and farmers exhibited increased risk of stomach cancer.

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