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20160516.exe. Aimbot, DFBHD and Hacks, dead link – “. 324 66 008 questinnotallGrammy Award for Best R&B Performance by a Duo or Group with Vocals
The Grammy Award for Best R&B Performance by a Duo or Group with Vocals is awarded to the best R&B performance that features a vocal by a duo or group of at least two performers. The award was introduced in 1989 and has been awarded annually since then.
Winners and nominees
1990s
2000s
2010s
References
Category:Grammy Awards for singing
Category:Awards established in 1989
Category:Awards disestablished in 2014
Category:Awards established in 2017
Category:Awards disestablished in 2019Substrate specificity of rat liver microsomal cytochrome P450 3A for steroids.
The metabolism of steroid hormones in the rat is mostly mediated by cytochrome P450 3A (CYP3A). In the present study we have examined the substrate specificity of the rat liver microsomal form of CYP3A for steroid hormones by means of the deconjugation of glucuronide and sulfate in 17 steroid hormones, 24 steroid intermediates and a variety of other mono and multisubstrate combinations. The deconjugation efficiencies for glucuronide of 16 steroids ranged from 1 to 90% in a wide range of pH and ionic strength. The deconjugation efficiencies for sulfate ranged from 14 to > 90% in a wide range of pH and ionic strength. The deconjugation of glucuronide was inhibited by carbon monoxide and the reductase inhibitor SKF-525 A, whereas the deconjugation of sulfate was inhibited by SKF-525 A. The deconjugation of glucuronide was stimulated by the CYP3A-selective substrate vinblastine, whereas the deconjugation of sulfate was stimulated by the CYP3A-selective substrate miconazole. The activation of steroid intermediates of steroid hormones by CYP3A was not in a manner consistent with an electrophilic mechanism, but the conversion of the corresponding hydroxylated derivatives to the corresponding glucuronide or sulfate derivatives seemed to be also catalyzed by this enzyme. The metabolism of a variety of mono and multi substrate combinations with steroid intermediates and eight other
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